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In metabolic disorders such as type 2 diabetes (T2D), microbial dysbiosis is characterized by an increase in Gram-negative Enterobacteriaceae and a reduction in short-chain fatty acid (SCFA)-producing bacteria such as Bifidobacterium, resulting in elevated circulating LPS levels and metabolic endotoxemia (Kahles et al., 2014

Interestingly, selective knockdown of GLP-1Rs in the supramammillary nucleus led to anxiolytic response, which was observed only in females [87]

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