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10.1016/j.biocel.2006.06.004 61 IsacchiB.FabbriV.GaleottiN.BergonziM

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In young and aged rats, treadmill exercise for a duration of 6 weeks led to increased SIRT1 activity, NAMPT and NAD + levels, and decreased mitochondrial generation of ROS 302

Duration ranges from 10 days to 30 days across laboratory study cycles, depending on observed biological response endpoints, tissue adaptation patterns, and research protocol structure requirements