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[6] Use of lidocaine HCl Injection is absolutely contraindicated in patients with documented hypersensitivity to amide-type local anesthetics or to any formulation excipients

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Common examples include: Depression combined with alcohol dependency, which often leads to self-medication cycles Anxiety disorder alongside prescription drug abuse, frequently starting with legitimate prescriptions Bipolar disorder co-existing with cocaine addiction, often triggered during manic episodes PTSD occurs with opioid dependency, commonly stemming from trauma-related pain management The relationship between these conditions often creates a complex cycle

Information summarized from existing preclinical and analytical literature

Shaking creates foam, and foam means air-liquid interfaces where peptide molecules unfold and aggregate