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Studies using physiologic end-points (direct G interactions with ion channels) in single opioid-sensitive neurons have also reported similar impaired MOR-effector coupling in a range of neuronal cell types from animals chronically treated with morphine in vivo, including rat and mouse periaqueductal gray (Bagley et al., 2005b

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For athletes, this means that the clearest upside is the "soft-tissue housekeeping" (i.e., skin and connective tissue) that may complement their recovery

"While omega-3 fatty acids are crucial for our overall health, it's generally better for people with type 2 diabetes to get their intake by eating at least two portions of oily fish a week, than by taking supplements." But Dr Carrie Ruxton, from the industry-funded Health and Food Supplements Information Service (HSIS), said: "While I would prefer people to follow the government's advice and eat more fish, this isn't the reality and a daily omega-3 supplement - whether from fish oil or algae - can bridge the gap."

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