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doi: 10.1111/sms.13373 566 McFarlinBKVenableASHenningALSampsonJNBPennelKVingrenJLet al

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( FIGURE 1 Growth hormone is mainly produced by the anterior pituitary gland, secreted in a pulsatile manner and under direct control of hypothalamic neuronal projections (Pombo et al., 2001), whose secretion is mainly regulated positively by growth hormone releasing hormone (GHRH), ghrelin ( 2+ signaling pathways (Zhu et al., 2001