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These molecules serve as methyl group donors, and their deficiency can lead to DNA, protein, and phospholipid hypomethylation, the degradation of telomere sequences, and disrupted amino acid and nucleotide metabolism [13]

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Depression patients also present increased TNF, macrophage colony-stimulating factor (MCSF), and IL-12 in the intestinal mucosa and reduced abundances of Clostridium, Roseburia, Haemophilus, SMB53 , and Turicibacter , which are positively correlated with propionate and butyrate levels [336]