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Kolijn D, et al

It has been demonstrated that the TP53 gene, located on chromosome 17, contributes to the maintenance of mitochondrial integrity, and that TP53 deficiency can be compensated for by an increase in aerobic glycolysis and an enhancement of mitochondrial mass ( One of the biological effects of CB-839 is the inhibition of glutathione synthesis due to the depletion of glutamate as the pivotal precursor for glutathione synthesis