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This schedule was validated in the SURMOUNT clinical trial program, which demonstrated average weight loss of 20 to 25 percent of body weight over 72 weeks at the highest doses

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Follow-up testing ensures adequate treatment without overcorrection

DKK1 antibody effectively corrects renal osteodystrophy, while PRI-724, an inhibitor of CBP/-catenin, inhibits the activation of hepatic astrocytes and delays the progression of liver cirrhosis