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Critically, this is especially relevant to GI-mediated complications commonly associated with neurodegenerative disorders, in which GI motility impairment, chronic low-grade inflammation, and intestinal nerve damage are widely observed (Matheis et al., 2020)

Now it is in your calves, and the burning keeps you awake at three in the morning

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Most clinical use is based on extrapolation from animal research and anecdotal reports from clinical practice

A phase 3 study (NCT04822181), which enrolled 1200 patients with biopsy-proven MASH and fibrosis, is currently ongoing to assess the benefit of OW subcutaneous semaglutide 2 mg in this setting 93