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Meanwhile, Acyl-coA synthetase long-chain family member 4 (ACSL4) esterifies PUFAs into phospholipids, expanding the pool of oxidizable substrates, while the 15-lipoxygenase(15-LOX)/phosphatidylethanolamine-binding protein 1 (PEBP1) complex catalyzes the formation of specific peroxidized PE species, serving as a persistent source of ROS [145]

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The sensitivity of lipid profiles in reflecting RA activity and response to disease-modifying anti/rheumatic drugs (DMARDs) (191)