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During liver stress, folate is released to repair damage, but this can cause inflammation

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As acetaminophen detoxification proceeds in this fashion, glutathione, a ubiquitous cellular antioxidant, eventually becomes depleted (Moyer 2011), and NAPQI can no longer be sufficiently detoxified (James 2003)

Seetharam D, Mineo C, Gormley AK, Gibson LL, Vongpatanasin W, Chambliss KL, Hahner LD, Cummings ML, Kitchens RL, Marcel YL, Rader DJ, Shaul PW

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