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placebo with respect to resolution of MASH without worsening of fibrosis [136, 137]

However, despite the rather modest weight loss with the drug in this trial, these patients with preserved ejection fraction heart failure demonstrated clinically significant improvements in quality of life, measures of functional capacity, reductions in important biomarkers including NT proBNP and CRP, and numerically less likelihood of heart failure decompensation. In the published paper, the researchers hypothesize that the weight-loss-independent benefits of semaglutide in HFpEF may include direct effects on decongestion

Alternative dosing regimens of GLP-1 receptor agonists may reduce costs and maintain weight loss efficacy

Previous studies of the weight-loss drug semaglutide hinted that people using either Ozempic or Wegovy had less troublesome alcohol cravings

Struggle with sustained weight loss through diet and exercise alone