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ADX71743 (12.5 and 100 mg/kg, subcutaneous injection, single dose) demonstrates bioavailability in C57Bl6/J mice, penetrates the blood-brain barrier (CSF/plasma concentration ratio was 5.3% at Cmax), shows linear increases in plasma exposure with increasing dose, and is cleared rapidly (half-life approximately 0.5 hours)

Further confirmation is required for the role of genotype and central and GI effects of GLP-1RA 112

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Therefore, more researches in the future are also needed to establish models in suitable animals, such as orangutans, which have similar physiological structures and physiological mechanisms as humans

The relationship between pain and depressive symptoms after lumbar spine surgery