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In some embodiments, the particle size of the formulation or composition described herein increases the retention time of the formulation or composition described herein

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The most likely candidates for the factors that mediate stimulation of the HPA axis after eating are the gut hormones which are released in response to enteral nutrients

Diabetes Care 46 , 209221 (2023)

If homocysteine turns out to cause inflammation and therefore joint pain, then vitamin B12 supplementation would be a consideration