The association of APR-246 and ferroptosis inducers has a synergistic anti-leukemic activity in vitro We next determined whether targeting ferroptosis pathways in combination with APR-246 can increase the antileukemic activity of this compound, mimicking SLC7A11 inhibition
Small Molecule TNF Inhibitors Suramin Suramin, a polysulfonated urea derivative, has traditionally been used in the treatment of trypanosomiasis (caused by trypanosome parasites) and onchocerciasis (river blindness due to Onchocerca volvulus infection)
doi: 10.1007/s12275-024-00173-6 414 KerryRGPatraJKGoudaSParkYShinHSDasG
proposed some optimization suggestions for sample preparation, elution, and detection (Homerin et al., 2021)
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