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Extreme concentration may impede nebulization and efficient delivery of the drug

For example, pairing it with vitamin C infusions can boost its effectiveness as an antioxidant

Long-term safety studies, however, have not been conducted (see Concerns and Cautions)

A 2017 systematic review and meta-analysis by Lanhers et al., published in Sports Medicine, confirmed that creatine supplementation significantly improves strength performance across multiple age groups and activity levels

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