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Deep vein thrombosis (DVT) typically presents with: Swelling in one leg (rarely both) Pain or tenderness, often starting in the calf Warmth and redness over the affected area Visible surface veins Leg feeling heavy or aching Pulmonary embolism (PE) , which occurs when a clot travels to the lungs, may cause: Sudden shortness of breath or difficulty breathing Sharp chest pain that worsens with deep breathing or coughing Rapid heart rate or palpitations Coughing up blood Feeling lightheaded or fainting Arterial thrombosis affecting coronary or cerebral circulation presents as: Chest pain, pressure, or discomfort (potential myocardial infarction) Sudden weakness or numbness, particularly on one side of the body Difficulty speaking or understanding speech Vision changes or loss Severe headache with no known cause It is important to note that these symptoms can occur in anyone with diabetes, regardless of which glucose-lowering medication they take