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In the landmark STEP 1 trial (Once-Weekly Semaglutide in Adults with Overweight or Obesity, Wilding and colleagues, New England Journal of Medicine , 2021), 1,961 adults who took weekly semaglutide (2.4 mg) plus lifestyle support lost a mean of 14.9% of their body weight over 68 weeks, compared with 2.4% on placebo, and 86% achieved at least 5% weight loss

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Collectively, these findings suggest that disease-associated mutations, though mechanistically diverse, converge in their impact on astrocytic reactivity by resetting the threshold at which astrocytes enter reactive states