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10.1055/s-0038-1650023 [DOI] [PubMed] [Google Scholar] Cook S

The mechanism appears to involve increased serotonin synthesis in substantia nigra (both compacta and reticulata), a regional pattern unlike any existing antidepressant drug, plus potential dopaminergic contributions given the nigrostriatal location

The liver is where excess B12 is stored and is used to regulate B12 levels

If a person is deficient due to insufficient B12, they may need to organize their diet to include more B12-rich foods or take an oral supplement