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The use of GSH depleting drugs such as DL-buthionine-S,R-sulfoximine, menadione or vitamin K 3 , sodium deoxycholate or diets enriched in fructose, which induce several features of the metabolic syndrome, produce inhibition of the intestinal Ca 2+ absorption

Future research is expected to shed more light into the potential benefits and uses of this NNMT inhibitor

Feb 2024;23(2):502-509

Notably, differential susceptibility to ferroptosis exists between cell types: endometriotic cells acquire resistance through upregulation of GPx4 and GSH, whereas granulosa cells remain vulnerable due to decreased antioxidant defenses (35, 36)