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Immunohistochemical staining and western blot analysis revealed that SNL increased the activation of microglia and astrocytes in the dentate gyrus of the hippocampus, along with elevated expression of pro-inflammatory cytokines such as TNF-, IL-1 and IL-6, which were significantly reversed by exendin-4 treatment [68]

Clinical Evidence Behind Oral GLP1 Agents In studies like the PIONEER trial series, oral semaglutide has shown robust improvements in A1C and body weight, with some formulations rivaling injectable alternatives

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This is particularly important for the functioning of muscles, including the heart

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