pioneer 3 semaglutide Efficacy and safety of oral vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: 12, a double-blind, Phase IIIa, randomised trial | Diabetologia First Time: Orally Available GLP-1

Some prefer oral medications, but the strict dosing requirements can be challenging

Data sources PubMed, Embase, The Cochrane Library, China National Knowledge Infrastructure (CNKI), WanFang Data, and VIP database were electronically searched from database inception to December 2023

Evidence Signals and What They Cannot Prove Yet Early research can show whether a medicine looks promising, but it cannot answer every practical question

Several mechanisms of action of TPM in relation to weight loss have been proposed, which include changes in the reward pathway associated with food, stimulation of lipoprotein lipase, and decreased leptin and blood glucose levels

Not for use in humans or animals