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Moreover, GLPs attenuate pathological reactive gliosisevidenced by suppressed activation of GFAP-expressing astrocytes and IBA-1-positive microgliaand help reestablish glianeuron crosstalk through the modulation of key intercellular communication proteins, including connexin 43 (Cx43) and aquaporin-4 (AQP4)

The acquisition of these and other transition metals is essential for the survival of the pathogen in host tissues, and during bacterial infection, a battle ensues between the pathogen and the host: the host responds to the pathogen by limiting the availability of metals, as part of an innate immunity strategy called nutritional immunity and the pathogen attempts to counter this maneuver by all means

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& McClung, J