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GLP-1 medications such as Ozempic are now widely marketed to help treat obesity, but there has also been a rise in companies selling unauthorised supplements or treatments

Why It Matters This is the first human study to show that GLP-1 medications may help the body burn visceral fat more actively not just reduce calories in.That means the weight loss benefits could be coming from both appetite control and a metabolic boost

Aleniglipron is in phase 2b trials, with data expected at the end of 2025

Inhibition of either mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) or phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/AKT) signaling pathway attenuated this effect

Gastric motility may take up to 4 weeks to normalize following GLP-1 RA withdrawal, yet discontinuation for such an extended period could compromise glycemic control and cardiovascular benefits