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Lebers disease

[7] Wall BT, et al

J Am Soc Nephrol 15(6):13921401 Lomashvili KA, Garg P, Narisawa S, Millan JL, ONeill WC (2008) Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification

Mitochondrial Energy Production Methylene blue acts as a backup route when mitochondrial energy production is damaged, maintaining stable ATP levels while reducing harmful free radical formation

Using various biochemical and biophysical approaches, we demonstrate that Syn WT engages in functional interactions, whereas C-terminal acidic tail truncated Syn 1103 and S129-phosphomimicking ( S129E ) mutant are reactive, displaying broad, non-functional aberrant binding and impairing chaperone-mediated refolding