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The vision loss is often permanent, which is why early recognition matters so much
Changes in Mood Some people notice feeling more irritable, anxious, or emotional
The dedicated FLOW trial of subcutaneous semaglutide in T2D-related CKD showed a 24% reduction in the composite of major kidney disease events (HR 0.76, 95% CI 0.660.88) and significant reductions in cardiovascular outcomes [22], supporting GLP-1RA therapy as an evidence-based addition for cardiorenal protection in this population
PE contributes to more than 100,000 deaths each year
Resmetirom, which was also approved in August 2025 by the European Medicines Agency (EMA), is indicated for the treatment of adults with noncirrhotic MASH with moderate to advanced fibrosis and has been administered to over 23 000 patients in the USA ( On August 15th, 2025, the FDA granted an accelerated and conditional approval of the subcutaneous glucagonlike peptide (GLP1) receptor agonist (GLP1RA) semaglutide 2.4 mg/week for the treatment of MASH with moderate to advanced fibrosis (Stage F2F3) [7]
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