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A clinician may consider discussing MOTS-c when the bigger pattern includes: Early insulin resistance markers or metabolic syndrome risk factors Weight gain paired with fatigue, despite stable routines Training that creates soreness, but not adaptation Sleep disruption that keeps the nervous system in high alert This is where a plan should be built with guardrails

J., Romero-Maldonado A., Monreal-Escalante E., Becerra-Flora A., Korban S