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A 2013 Cochrane review performed on 52,044 randomized participants showed limited positive effects of the MedDiet on cardiovascular risk (66), whereas in the same year a meta-analysis performed on 3,073 randomly assigned individuals with different dietary regimes showed that the MedDiet as well as diets characterized by low-glycemic index, low-carbohydrate and high-protein determined an improvement in cardiovascular risk factors in patients with diabetes (67)

Microbisporicin has an additional valuable property: it enhances the activity of PMs antibiotics against Gram-negative bacteria, with observed synergistic effects between the two compounds

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