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Recovery requires tissue repair, inflammation control, and growth factor activation working together

Hence, while oral semaglutide and SGLT2 inhibitors offer comparable benefits for glycemic control and weight reduction, clinicians must consider the potential for skeletal muscle loss when prescribing SGLT2 inhibitors, particularly in those vulnerable to sarcopenia or frailty

M.ProotP.ChiangY.StumvollM.Del PratoS.et al (2019)

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OS-induced glycolysis and inflammation are exacerbated by aging Hypoxia-inducible factor (HIF)-1 is a critical transcription factor responsive to hypoxia and mechanical forces, notably shear stresses, and plays a central role in EC metabolic adaptation during atherosclerosis and aging [220, 221]