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Potential serious adverse reactions include: Pancreatitis Gallbladder disease Severe gastrointestinal symptoms Dehydration Kidney injury related to dehydration Allergic reactions Animal studies demonstrated thyroid C-cell tumors, although it remains uncertain whether this risk applies to humans

Caffeine is a non-selective inhibitor of phosphodiesterase (PDE) enzymes involved in the inactivation of cAMP and cyclic guanosine monophosphate (cGMP) with the formation of 5-AMP and 5-GMP

Journal of Molecular Structure: TheochEM, 895, 86-91

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