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Additionally, they are all broken down similarly by dipeptidyl peptidase-4 (DPP-4) though GIP breakdown occurs at a slower rate than GLP-1 breakdown [16]

Since thyroid hormone uptake in the pituitary is relatively unaffected by outside factors, the presence of intracellular hypothyroidism is not reflected by TSH testing, which is why TSH is a poor marker for cellular thyroid function in any tissue other than the pituitary

Given that our animal model progressive deterioration of -cell dysfunction [38], we speculate that in the context of severe insulin resistance and compromised islet function, GLP-1RA responsiveness is inherently reduced

CONCLUSIONS In adults with obesity, retatrutide treatment for 48 weeks resulted in substantial reductions in body weight