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If cycling were necessary, it would have appeared during: Preclinical toxicology studies Human obesity trials Long-term safety evaluations It did not

Drug-Induced Lupus High doses of hydralazine, procainamide and isoniazid can cause lupus symptoms in those who do not have SLE

Inhibition of these cytokines also reduces surface expression of cellular adhesion molecules, reducing migration of activated lymphocytes into synovial tissue in PsA, and limiting the bone and cartilage damage by proteases released by these inflammatory cells

Still, for people with copper-metabolism disorders or with repeated/systemic exposure, copper burden is a real theoretical concern that has not been studied in humans