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individuals with pre-existing retinopathy should be aware of this risk [28] [29] Pregnancy and breastfeeding incretin-based therapies should be avoided during pregnancy and breastfeeding unless within a supervised clinical trial, as safety data in these populations are absent Delayed gastric emptying a class effect of GLP-1 receptor agonists can reduce the absorption rate of concomitant oral medicines
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Antioxidant responses, particularly those initiated by Nuclear Factor Erythroid 2-related Factor 2 (NRF2) signaling, have been demonstrated to play a pivotal role in restoring redox balance and constraining the progression of fibrosis or HCC (Kundu and Surh 2010)
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