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25 In line with the role of ADAMTS-2 as an important procollagen type I N-endopeptidase, 9,12,17 we found abnormal processing of the N-propeptide of type I procollagen, with accumulation of pN1(I) and pN2(I) procollagen chains and near-absence of pC1(I) and pC2(I) procollagen chains in patients derived fibroblasts

This supports the concept that -arrrestin-dependent trafficking of GLP1R limits the action of GLP1R activation on insulin secretion

Bishop JB, Phillips LG, Mustoe TA, et al

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