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Based on this finding, the most recent 2018 recommendations from the American Diabetes Association state that compared with basal-plus insulin, basal insulin plus GLP-1 RAs are associated with less hypoglycemia and with weight loss instead of weight gain but may be less tolerable and have a greater cost [2]

Increasing your dose when your body is responding optimally may introduce unnecessary side effects without additional benefit

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Fourth, long-term clinical outcomes data - cirrhosis incidence, HCC rates, liver transplantation, and liver-related mortality assessed as primary endpoints in randomized trials - are not yet available and are urgently needed to move beyond surrogate histological endpoints

At 48 weeks, the decrease was 8.7% to 24.2% versus 2.1% with placebo