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Despite initially promising results, SAR425899 has been discontinued after phase 2 trials showed treatment related gastrointestinal disorders (NCT03437720)

CQ can form a stable complex with Cu(II), namely CuCQ, which exhibits potent cytotoxicity in human cancer cell lines (MCF10DCIS.com), ovarian cancer (A2780), and lung cancer (A549) cells (Zhai et al., 2010

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Histamine is the most common mediator released by mast cells in response to allergens such as pollen