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Furthermore, anticholinergic medications, such as trihexyphenidyl, are used also in PD management but struggle to effectively cross the BBB and often exhibit non-specific binding, leading to undesirable peripheral effects such as dry mouth and cognitive impairment, particularly in elderly patients

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10.3389/fonc.2021.745262 23 BajajJ

If you respond well to standard doses, using intensive doses just burns through expensive product faster without proportional benefit