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However, returning appetite and reduced fullness signals may cause hunger, food cravings, and rapid weight regain, which can feel psychologically challenging

Some patients notice small appetite changes during the first week

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Figure 2 Further analysis of suicidal ideation or attempts at 3, 6, and 12 months revealed adjusted hazard ratios of 0.04 (95% CI: 0.020.08), 0.07 (95% CI: 0.040.13), and 0.12 (95% CI: 0.080.20), respectively, demonstrating a consistent reduction in risk over time in the tirzepatide group compared to the control group ( Table 2 )

It is also not appropriate for those who are looking for an instant or short-term weight loss fix