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As previously noted, innate immune cells like DCs prime these CD8 + T cells by presenting melanocyte antigens via MHC class I

Oxidative stress is thought to damage melanocytes and trigger inflammatory responses, culminating in melanocyte immune-mediate destruction

Systemic reduction in glutathione levels occurs in patients with primary open-angle glaucoma

Stabilizing them, preventing inappropriate degranulation while maintaining their legitimate immune functions, is the holy grail of allergy treatment

Therefore, the dispensability of SLC7A11 in normal systems and its high expression in various cancers makes it an attractive therapeutic target for cancer treatment