This lack of significant improvement may be attributed to the activation of VEGF-independent angiogenic pathways, the recruitment of proangiogenic stromal cells, the induction of vasculogenesis or even the dose of the antiangiogenic agent used, which may reduce the size of blood vessel pores, further obstructing the delivery of this antibody [30, 39, 40]
Ethics declarations Conflict of interest Drs Ji-Guang Wang and Yan Li reports having received consulting and lecture fees from Viatris China (Shanghai, China)
However, its clinical application must be approached with a critical and nuanced understanding of the current evidence gap
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