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You might not think much about your digestive system daily
The Jastreboff Phase 2 trial randomised 338 adults with body mass index 30 (or 27 with at least one weight-related condition) to retatrutide 1, 4, 8, or 12 mg subcutaneously once weekly, or placebo, for 48 weeks
Kavanaugh A, Antoni CE, Gladman D, et al
Quick Answer: Most patients see blood glucose improvements within 14 weeks of starting GLP-1 therapy, while noticeable weight loss typically becomes apparent after 46 weeks, with peak effects at 6072 weeks
The MHRA product information for Wegovy notes that these symptoms are typically transient and most pronounced when initiating treatment or increasing the dose
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