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It's derived from common plants such as cinnamon, mint, citrus, and lavender

9, 957-964 Thomsen RW, et al

Since skin steroidogenesis can be modulated by external factors and is locally restricted, there is a tremendous potential for novel topical therapeutic approaches targeting skin estrogen biosynthesis to achieve local estrogen healing benefits without off-target effects which are undesirable in both men and women, as explained in the following section

The FDA-approved dosing schedule involves gradual increases every four weeks, but individual tolerance varies

But theres a growing interest in documenting these benefits