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In this work, we emulated a target clinical trial comparing rate of acute healthcare utilization, all-cause mortality, composite cardiovascular events, and kidney disease progression in patients with moderate to advanced CKD initiating GLP1-RAs versus DPP4is in real world practice within the Veterans Healthcare Administration (VHA)

and (4) the integration of advanced technologies, including AI-assisted diagnostics, multi-omics approaches such as spatial transcriptomics and proteomics, and patient-derived organoids (PDOs), is driving metabolism-guided precision medicine

-cell dedifferentiation in patients with T2D with adequate glucose control and nondiabetic chronic pancreatitis

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