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Forms of berberine (and a couple of branded extracts) Berberine generally comes in one of four forms: Pure berberine: the natural alkaloid form extracted from the parts of berberine-rich plants Berberine hydrochloride (HCl): the salt form created by combining berberine with hydrochloric acid improved water solubility and, therefore, better absorption in the body

"Partition and turnover of glutathione reductase from Saccharomyces cerevisiae: a proteomic approach" (PDF)

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doi: 10.1146/annurev.biochem.71.102301.093055

The AUC values of the compound preparations were 240.6 and 133.0 gh/ml, respectively, while the mean residence times were 3.192 min and 3.259 min, respectively (117)