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Algunos marcadores de senescencia celular son niveles intracelulares incrementados de ADN de doble hebra daado y fragmentado, de lipofuscina, de inhibidores del ciclo celular, como p16 y p21, y la presencia de un fenotipo secretor proinflamatorio

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By blocking GSK3-beta, valproic acid allows more beta-catenin to accumulate and reach the nucleus