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The modulatory effects of L-carnitine combined with trimetazidine balanced the glycolysis and oxidation of fatty acids, and the major effects involved in metabolic pathways are Warburg effect, the TCA cycle, inositol phosphate metabolism, phenylalanine and tyrosine metabolism, purine metabolism, arginine and proline metabolism, glycol metabolism, branched-chain amino acid degradation, and fatty acids metabolism (Figures 6B,D)

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