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Similarly, supplementation of RPM (Smartamine) for Holstein multiparous cows during the transition period followed by the removal of RPM supplementation until day 72 postpartum, showed a decrease in global DNA methylation compared to cows that did not receive RPM supplementation during the entire period of evaluation (Acosta et al., 2016)

Rush JW, Sandiford SD

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Safety Across Different Populations The clinical trial program predominantly enrolled individuals with clinical obesity, providing safety data specifically in this population

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