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Preclinical and phase 1/2 showed that inhibition of potassium flow through the Gardos channel increased Hb levels and decreased hemolysis (ClinicalTrials.gov Identifier: NCT00040677)

It is a part of a class of drugs known as GLP-1 receptor agonists, which work by mimicking a hormone in the body that helps control blood sugar levels

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The efficacy of antifolate antimalarial combinations in Africa: a predictive model based on pharmacodynamic and pharmacokinetic analyses

Shorter cycles do not allow enough time for dose titration, steady-state achievement, and meaningful therapeutic effect