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Tirzepatide reconstitution by vial size (units assume U-100 insulin syringes) Vial 5 mg BAC water 1.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL / 50 u 5 mg 1.00 mL / 100 u 7.5 mg 10 mg 15 mg Vial 10 mg BAC water 1.0 mL Concentration 10 mg/mL 2.5 mg 0.25 mL / 25 u 5 mg 0.50 mL / 50 u 7.5 mg 0.75 mL / 75 u 10 mg 1.00 mL / 100 u 15 mg Vial 10 mg BAC water 2.0 mL Concentration 5 mg/mL 2.5 mg 0.50 mL / 50 u 5 mg 1.00 mL / 100 u 7.5 mg 10 mg 15 mg Vial 15 mg BAC water 1.5 mL Concentration 10 mg/mL 2.5 mg 0.25 mL / 25 u 5 mg 0.50 mL / 50 u 7.5 mg 0.75 mL / 75 u 10 mg 1.00 mL / 100 u 15 mg 1.50 mL / split Vial 40 mg BAC water 2.0 mL Concentration 20 mg/mL 2.5 mg 0.125 mL / 12.5 u 5 mg 0.25 mL / 25 u 7.5 mg 0.375 mL / 37.5 u 10 mg 0.50 mL / 50 u 15 mg 0.75 mL / 75 u Vial 40 mg BAC water 3.0 mL Concentration 13.33 mg/mL 2.5 mg 0.188 mL / 18.8 u 5 mg 0.375 mL / 37.5 u 7.5 mg 0.563 mL / 56.3 u 10 mg 0.75 mL / 75 u 15 mg 1.125 mL / split Vial 60 mg BAC water 3.0 mL Concentration 20 mg/mL 2.5 mg 0.125 mL / 12.5 u 5 mg 0.25 mL / 25 u 7.5 mg 0.375 mL / 37.5 u 10 mg 0.50 mL / 50 u 15 mg 0.75 mL / 75 u 20 mg/mL keeps 40 mg and 60 mg vial setups within a 3 mL vial-capacity ceiling while keeping the listed doses compact

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Choline is an essential nutrient which is absorbed in the upper small intestine by specific enterocyte transporters via facilitated (Radziejewska and Chmurzynska, 2019), only excessive amounts are metabolized into TMA by the gut microbiota in the colon (Papandreou et al., 2020)

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