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Dry is essential

Thymosin alpha-1 is now prescribed worldwide for a variety of conditions involving immune support (long COVID, chronic Lyme, chronic mono, chronic fatigue syndrome, and a host of viral, bacterial, parasitical/fungal/candida infections and even cancer)

For example, a study that used dried leaf revealed a decrease in the frequency of migraines while another using a CO2 extract did not show significant benefit (Pittler 2004)

Observed associations are not consistent across all models (Bhm, 2026)

Without direct tissue quantification, it is unknown if the CNS exposure was high, or if the large systemic dose simply compensated for low anatomical delivery efficiency across the nasal mucosa